119 tools — free for scientists
Precision tools for
drug development
PK/PD calculators, DMPK analysis, regulatory intelligence, and clinical pharmacology — built for scientists who need answers, not software training.
0
Tools
0
Domains
0
Agencies
Free
Cost
Regulatory Intelligence
Enterprise-grade regulatory tools — free. Replaces $30K/yr platforms.
Guidance Search
Multi-agency regulatory guidances with AI summaries
Open tool
Drug Approvals
FDA, EMA, HC timelines with cross-agency comparison
Open tool
Patent Intelligence
Generic entry analysis and patent thicket scoring
Open tool
Safety Signals
FAERS PRR/ROR disproportionality analysis
Open tool
Clinical Trials
PK study classification from ClinicalTrials.gov
Open tool
Drug Labels
SPL parsing with section-level comparison
Open tool
All Tools by Domain
Browse all 119Clinical Pharmacology
10Renal Dose Adjustment
Predict dose modifications for renal impairment studies per FDA/EMA guidance. Dettli method with CKD staging for special population sections
Hepatic Dose Adjustment
Child-Pugh classification and dose adjustment rationale for hepatic impairment clinical pharmacology studies and NDA submissions
Pediatric Dose Calculator
Calculate pediatric dose scaling using BSA, weight-based, and age-adjusted methods for Pediatric Study Plan (iPSP) dose justification and clinical trial design
Obesity Dosing Calculator
Compare IBW, ABW, LBW, and BSA-based dosing strategies for weight-based dose selection in clinical development programs
Elderly Dose Adjustment
Age-adjusted pharmacokinetic considerations and CrCl estimation for geriatric sub-population analysis in clinical pharmacology reviews
Clinical Loading Dose
Calculate loading dose with current level accounting for first-in-human dose selection rationale and clinical trial protocol design
PK Calculators
10Half-Life Calculator
Calculate drug elimination half-life from Ke, two C-t points, or CL and Vd
AUC Calculator
Calculate area under the curve using linear trapezoidal, log-linear, or mixed methods
Clearance & Vd Calculator
Calculate systemic clearance and volume of distribution from PK data
Bioavailability Calculator
Calculate absolute and relative bioavailability from AUC comparisons
Steady-State Calculator
Predict time to steady state and accumulation from dosing regimen
Accumulation Ratio Calculator
Calculate drug accumulation factor from half-life and dosing interval
DMPK
15IVIVE Hepatic Clearance
In vitro to in vivo extrapolation of hepatic clearance using well-stirred model
Microsomal Stability Predictor
Predict in vivo clearance from microsomal stability half-life data
Hepatocyte Stability CL
Predict in vivo clearance from hepatocyte stability data using HPGL scaling and well-stirred model
DDI Risk Assessment (FDA)
FDA static model R1/R2/R3 for CYP inhibition and induction risk classification
Enzyme Kinetics Calculator
Calculate Km, Vmax, and CLint from Michaelis-Menten kinetics data
fu,mic Correction Calculator
Calculate fraction unbound in microsomes for IVIVE correction
Drug Discovery & ADMET
8ADMET Quick Profile
ML-based ADMET property prediction from SMILES or drug name via ADMETlab 3.0
Drug-Likeness Analyzer
Evaluate Lipinski, Veber, Egan, Ghose drug-likeness rules with QED and SA scores
CYP Inhibition Predictor
Predict CYP1A2, 2C9, 2C19, 2D6, 3A4 inhibition and substrate status from molecular structure
BBB Penetration Estimator
Predict blood-brain barrier penetration probability and CNS MPO score
hERG Liability Predictor
Predict hERG channel inhibition probability and QT prolongation risk from structure
ML Property Predictor
Predict molecular ADMET properties using consensus ML models (ChemBERTa + ADMETlab) from SMILES or drug name
Biologics PK
6TMDD Simulator
Target-mediated drug disposition model for monoclonal antibodies
mAb Allometric Scaling
Scale monoclonal antibody PK parameters across species using allometry
mAb Half-Life Estimator
Estimate monoclonal antibody half-life from FcRn binding and IgG subclass
SC/IV Bioavailability Estimator
Estimate subcutaneous bioavailability relative to IV for biologics
ADC PK Complexity Visualizer
Visualize antibody-drug conjugate PK: total antibody, conjugated antibody, and free payload profiles with DAR effects
FcRn Binding Impact Calculator
Estimate mAb half-life from FcRn binding affinity (KD at pH 6.0), isoelectric point, and molecular weight
PK/PD Simulators
61-Compartment IV Simulator
Simulate IV bolus and infusion concentration-time profiles
1-Compartment Oral Simulator
Simulate oral absorption with first-order Ka and elimination
2-Compartment Simulator
Two-compartment PK model with distribution and elimination phases
Emax PD Simulator
Simulate Emax, sigmoid Emax, and effect-compartment PD models
Target Attainment Simulator
Simulate probability of target attainment for PK/PD endpoints
IV vs Oral Comparison
Compare IV and oral dosing profiles side by side for bioequivalence
Pharmacometrics
7AIC/BIC Model Comparison Calculator
Compare pharmacokinetic models using AIC, BIC, and likelihood ratio test from OFV
Shrinkage Calculator
Calculate eta-shrinkage and epsilon-shrinkage from NONMEM PopPK model output
IIV Calculator
Convert omega² to CV%, SD, and geometric CV for PopPK models with typical parameter ranges
Covariate Effect Visualizer
Visualize covariate effects on PK parameters as a forest plot with clinical significance bounds
Residual Diagnostics
Analyze CWRES and IWRES residuals from NONMEM PopPK models for bias and outlier detection
VPC Interpretation Guide
Learn to interpret Visual Predictive Checks with annotated examples covering good fit, overprediction, and pcVPC
Bioequivalence
11BE Sample Size Calculator
Calculate required subjects for bioequivalence studies with power analysis
ANOVA for Bioequivalence
Compute 2x2 crossover ANOVA decomposition for BE studies with F-tests, p-values, intra-subject CV%, and MSE
BE Assessment from Summary Statistics
Calculate 90% CI for bioequivalence from summary statistics (GMR, CV%, N) using TOST procedure
GMR & 90% CI Calculator
Calculate geometric mean ratio and 90% confidence interval for bioequivalence against 80-125% limits
HVD RSABE Calculator
Calculate reference-scaled average bioequivalence for highly variable drugs with Swr threshold and scaled limits
NTI BE Calculator
Calculate bioequivalence for narrow therapeutic index drugs with tightened 90-111% limits
Antimicrobial PK/PD
6fT>MIC Calculator
Calculate percentage of dosing interval with free drug above MIC for time-dependent antimicrobials
AUC/MIC Ratio Calculator
Calculate AUC/MIC and fAUC/MIC ratios for vancomycin TDM, fluoroquinolone dosing, and AUC-guided therapy
Cmax/MIC Ratio Calculator
Calculate Cmax/MIC and fCmax/MIC ratios for aminoglycoside dose optimization and once-daily dosing
Monte Carlo PTA Simulator
Population-level Monte Carlo simulation of probability of target attainment across dose and MIC ranges
Antimicrobial Breakpoint Lookup
Look up EUCAST MIC breakpoints with PK/PD indices and targets for common organism-antibiotic combinations
Antimicrobial Dosing Optimizer
Optimize antimicrobial dosing regimens based on PK/PD targets for beta-lactams, fluoroquinolones, aminoglycosides
Pediatric PK
6CYP Maturation Calculator
Calculate CYP enzyme maturation fraction (Fmat) by age using the Hill equation for CYP3A4, CYP2D6, CYP1A2, CYP2C9, CYP2C19
UGT Maturation Calculator
Calculate UGT enzyme maturation (UGT2B7, UGT1A1, UGT1A6, UGT1A9) by age using the Hill equation
Pediatric Allometric Scaling
Scale adult doses and clearances to pediatric values using allometric, Anderson & Holford, BSA-based, and linear per-kg methods
Pediatric GFR Suite
Calculate pediatric eGFR using Schwartz, FAS, and CKiD U25 equations with CKD staging
Neonatal PK Adjustor
Comprehensive neonatal physiological maturation assessment: GFR, CYP activity, protein binding, body water, gastric pH
Pediatric Study Regulatory Guide
Determine pediatric study requirements under FDA PREA/BPCA and EMA PIP with age groups, study types, and waivers
Safety & Exposure
5Therapeutic Index Calculator
Calculate Therapeutic Index (TD50/ED50) and Certain Safety Factor (TD1/ED99) for drug safety margins
Exposure Margin Calculator
Calculate AUC and Cmax exposure margins from animal NOAEL to human therapeutic dose per ICH M3/S9
First-in-Human Dose Calculator
Calculate maximum recommended starting dose (MRSD) for first-in-human trials using FDA BSA or allometric methods
Concentration-QTc Visualizer
Perform concentration-QTc analysis with linear regression, 90% CI, and ICH E14 threshold assessment
Exposure-Response Explorer
Fit logistic regression to binary exposure-response data with EC50, odds ratio, and predicted probabilities
Formulation & Biopharmaceutics
3Food Effect Study Designer
Predict food effect direction and magnitude based on BCS class, logP, and formulation type with FDA meal specs
Formulation Change Dose Adjuster
Estimate dose adjustments when switching formulation types (IR, ER, DR, ODT) based on BCS and relative bioavailability
IVIVC Correlator
Fit Weibull dissolution models and establish IVIVC (Level A/B/C) between in vitro dissolution and in vivo absorption
Built for your work
DMPK Scientists
IVIVEDDI Risk
Clinical Pharmacologists
Dose AdjustmentQTc
Pharmacometricians
TMDDPopPK
Regulatory Scientists
Guidance SearchApprovals
Clinical Pharmacists
CrCl/eGFRRenal Dosing
Students & Educators
Half-LifeClearance
Built by pharmaceutical scientists. Equations verified against published literature. Interpretation rules peer-reviewed.
Start with one calculation.
No account required. No credit card. No setup.