Enzyme maturation, allometric scaling, GFR, neonatal PK, and regulatory guidance
Calculate CYP enzyme maturation fraction (Fmat) by age using the Hill equation for CYP3A4, CYP2D6, CYP1A2, CYP2C9, CYP2C19
Calculate UGT enzyme maturation (UGT2B7, UGT1A1, UGT1A6, UGT1A9) by age using the Hill equation
Scale adult doses and clearances to pediatric values using allometric, Anderson & Holford, BSA-based, and linear per-kg methods
Calculate pediatric eGFR using Schwartz, FAS, and CKiD U25 equations with CKD staging
Comprehensive neonatal physiological maturation assessment: GFR, CYP activity, protein binding, body water, gastric pH
Determine pediatric study requirements under FDA PREA/BPCA and EMA PIP with age groups, study types, and waivers