Core pharmacokinetic parameter calculations
Calculate drug elimination half-life from Ke, two C-t points, or CL and Vd
Calculate area under the curve using linear trapezoidal, log-linear, or mixed methods
Calculate systemic clearance and volume of distribution from PK data
Calculate absolute and relative bioavailability from AUC comparisons
Predict time to steady state and accumulation from dosing regimen
Assess dose-exposure linearity using power model and confidence intervals
Simulate concentration-time profiles for repeated oral or IV dosing
Calculate mean residence time, mean absorption time, and absorption rate constant
Calculate drug accumulation factor from half-life and dosing interval
Calculate IV infusion rates, drip rates, and target steady-state concentrations