Calculate drug elimination half-life from Ke, two C-t points, or CL and Vd
Calculate drug accumulation factor from half-life and dosing interval
Predict in vivo clearance from microsomal stability half-life data
Estimate monoclonal antibody half-life from FcRn binding and IgG subclass
Calculate required washout period based on drug half-life for crossover studies
Estimate mAb half-life from FcRn binding affinity (KD at pH 6.0), isoelectric point, and molecular weight