PopPK model diagnostics, shrinkage, covariate analysis, VPC interpretation
Compare pharmacokinetic models using AIC, BIC, and likelihood ratio test from OFV
Calculate eta-shrinkage and epsilon-shrinkage from NONMEM PopPK model output
Convert omega² to CV%, SD, and geometric CV for PopPK models with typical parameter ranges
Visualize covariate effects on PK parameters as a forest plot with clinical significance bounds
Analyze CWRES and IWRES residuals from NONMEM PopPK models for bias and outlier detection
Learn to interpret Visual Predictive Checks with annotated examples covering good fit, overprediction, and pcVPC
Calculate D-optimal sampling times for PK studies to maximize Fisher Information Matrix